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Colchicine is an alkaloid obtained from the plant colchicum autumnale. It is a medication most commonly used to treat gout. It is a toxic natural product and secondary metabolite, originally extracted from plants of the genus Colchicum (autumn crocus, Colchicum autumnale, also known as "meadow saffron"). Colchicine is soluble in water and alcohol.
- Chemical Name: (S)-N-(5,6,7,9- tetrahydro-1,2,3,10-tetramethoxy-9 oxobenzol[a]heptalen-7-yl) acetamide
- CAS Number: 64-86-8
- Formula: C22H25NO6
- Molar mass: 399.437
- Form: White powder
Delivery Detail: Within 5 days after receipt of payment
The drug colchicine treats gout and Behçet's disease. As a gout treatment, it is less preferred than NSAIDs or steroids. Colchicine is also used to treat pericarditis and familial Mediterranean fever. The drug is taken orally.
A prescription drug called Colcrys is colchicine oral tablet. There is a generic version as well. Drugs that are generic are typically less expensive. The generic version may not be available in the same strength or form as the brand-name version.
Capsules of colchicine are also available. They are marketed under the brand name Mitigare. It also comes in generic form.
- Formula: C22H25NO6
- CAS ID: 64-86-8
- Elimination half-life: 26.6-31.2 hours
- Metabolism: Metabolism, partly by CYP3A4
- Protein binding: 35-44%
- Excretion: Faeces (65%)
- DrugBank: DB01394
How does it work?
A class of drugs called anti-gout medications includes colchicine. An entire class of drugs works in a similar way. The drugs are often used to treat similar conditions. Colchicine's mechanism of action is unknown. Immune cells are likely to be prevented from causing pain and inflammation by it.
Applications Or where it is used:
Colchicine is an effective treatment for symptoms of gout or familial Mediterranean fever. Familial Mediterranean fever is inherited in families. Inflammation (pain and swelling) can occur in both joints and lungs as well as the abdomen (stomach area).
Gout can also be treated with colchicine. The condition is caused by uric acid crystallizing in the joints, typically resulting in pain.
Combination therapies may include colchicine. You may need to take it with other medications.
Gout and some other inflammatory conditions benefit from the use of colchicine, a plant alkaloid that is extracted from autumn crocuses and glory lilies. When not used correctly, it is associated with significant toxicity.
How to use:
You will need to adjust your dosage, the form of the drug, and how often you take it based on:
- Condition being treated
- Severity of the condition
- Other existing medical conditions
- How one reacts to the first dose
Dosage of usage:
Remind yourself to take your dose as soon as possible. Take only one dose if you remember just a few hours before your next scheduled dose. You should never double dose to catch up as it may result in dangerous side effects.
Most common side effects:
- Abdomen pain
Warnings and precautions while using this product :
For pregnant women: Colchicine belongs to category C pregnancy drugs. This means two things:
- The drug has been shown to adversely affect the fetus when the mother takes it.
- The effects of this drug on a developing fetus have not been fully studied in humans.
If you are pregnant or plan to conceive, consult your doctor. Whenever possible, this drug should be used only if it justifies the potential risks to the fetus. In the event of pregnancy, contact your doctor immediately.
For women who are breastfeeding: Colchicine can pass into breast milk, causing side effects in breast-fed children. Talk to your doctor if you are breastfeeding. There may be a need to stop breast-feeding or take this medication.
For seniors: Elderly individuals' kidneys may not perform as well as they used to. Drugs may therefore be processed more slowly by the body. Therefore, the drug stays in your system longer. They are therefore more likely to experience side effects.
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