Difluprednate API

Difluprednate :-

Difluprednate is a corticosteroid, It is chemically a butyrate ester of 6,9-difluoro prednisolone acetate. Accordingly, difluprednate is sometimes abbreviated DFBA, for difluoroprednisolone butyrate acetate. 

CAS ID: 23674-86-4

ChemSpider ID: 391990

ChEMBL Id: 1201749

PubChem CID: 32037

Molecular Formula: C₂₇H₃₄F₂O₇ nih.gov

Molecular Weight: 508.5 g/mol nih.gov

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Difluprednate is a topical corticosteroid and prednisolone acetate derivative, with anti-inflammatory activity. Upon instillation into the eye, difluprednate binds to and activates the glucocorticoid receptor (GR). The receptor-ligand complex binds to promoter regions of certain genes and initiates RNA transcription. This results in an induction of synthesis of phospholipase A2 inhibitory proteins, thereby inhibiting the synthesis of arachidonic acid and preventing the synthesis of certain inflammatory mediators, such as prostaglandins and leukotrienes. This reduces ocular inflammation and pain.

Difluprednate ophthalmic comes as an emulsion (liquid) to apply to the eye. It is usually applied to the affected eye(s) 4 times a day beginning 24 hours after surgery and continuing for 2 weeks, and then 2 times a day for 1 week. Your doctor will probably decrease your dose gradually depending on your condition and how you respond to treatment. Use difluprednate eye drops at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use difluprednate ophthalmic exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

When you use difluprednate eye drops, be careful not to let the tip of the bottle touch your eyes, fingers, face, or any surface. If the tip does touch another surface, bacteria may get into the eye drops. Using eye drops that are contaminated with bacteria may cause serious damage to the eye or loss of vision. If you think your eye drops have become contaminated, call your doctor or pharmacist.